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Proffered Abstract (Oral Presentation): Anticancer Effects of Tea and Tea Constituents

Inhibition of intestinal tumorigenesis in Apc ^Min/+ mice by voluntary exercise and its combination with (-) -epigallocatechin-3-gallate consumption.

Rutgers, The State University of New Jersey, Susan Lehman Cullman Laboratory for Cancer Research, Piscataway, NJ; Rutgers, The State University of New Jersey, Departments of Neuroscience, Piscataway, NJ; Cancer Institute of New Jersey, New Brunswick, NJ; Rutgers, The State University of New Jersey, Department of Psychology, Piscataway, NJ

Abstract

PR-13

Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Animal studies, however, are not conclusive. The present study investigated the effects of voluntary exercise and its combination with (-)-epigallocatechin-3-gallate (EGCG) on intestinal tumor formation in Apc^Min/+ mice. In female Apc^Min/+ mice maintained on the AIN93G diet, 6-weeks of voluntary exercise, starting at 5 weeks of age, decreased the number of small intestinal tumors by 30%. The combination of exercise with oral administration of 0.32% EGCG fluid significantly reduced small intestinal tumor formation by 45% (p<0.05), and the effect was greater than that produced by either voluntary exercise (30%) or EGCG administration (26%). The EGCG treatment also increased the level of exercise in Apc^Min/+ and wild-type mice. In a 9-week experiment with mice maintained on a high-fat diet, voluntary exercise resulted in a 29% decrease in the total number of small intestinal tumors (p=0.05). The decrease (52%) in the number of larger tumors (>2 mm; p<0.005) was more prominent than that in the number of smaller tumors. Voluntary exercise decreased regional body fat pad weights by 26-51%, the molar ratio of serum insulin like growth factor (IGF)-1 to IGF binding protein-3 levels by 26%, and serum levels of leukotriene B₄. It also decreased levels of prostaglandin E₂ and nuclear ß-catenin, but increased levels of E-cadherin in the small intestinal tumors. These results indicate that voluntary exercise inhibited intestinal tumorigenesis in Apc^Min/+ mice maintained on a low- or high-fat diet, and the effect was enhanced by EGCG (support by NIH grant CA 88961 and ES05022).