Diagnostic Technologies and Molecular and Cellular Profiling: Bioinformatics:

Ruth Lyons, Helena Kempski, John Anderson, and Mike Hubank

Diagnosing pediatric leukemia: Clinical application of microarray data
AACR Meeting Abstracts 2006 2006: A1. [Abstract]  

Preclinical Studies and Early Drug Development: In Vitro and In Vivo Assays and Models:

Qiwei Yang, Yufeng Tian, Shuqing Liu, Rana Zeine, Alexandre Chlenski, Helen R. Salwen, Jack Henkin, and Susan L. Cohn

Suppression of malignant phenotype of human neuroblastoma by thrombospondin-1 peptide in combination with valproic acid
AACR Meeting Abstracts 2006 2006: B1. [Abstract]  

Antonio Jimeno, Belen Rubio-Viqueira, Xiang Feng Zhang, Audrey Chan, Saeed Khan, Kris Galvin, Wells Messersmith, Soner Altiok, Peter Kulesza, Anirban Maitra, and Manuel Hidalgo

Individualizing therapy using direct xenografting of pancreas cancers: a multi-modality approach
AACR Meeting Abstracts 2006 2006: B2. [Abstract]  

Wenrui Duan, Li Gao, Xin Wu, Gregory A. Otterson, and Miguel A. Villalona-Calero

Mutant type specific lung cancer models for individualized treatment
AACR Meeting Abstracts 2006 2006: B3. [Abstract]  

Xiaoying Yin, Hong Zhang, Francis Burrows, and Carol G. Shores

The effect of EC78, a novel Hsp90 inhibitor alone and in combination with radiation in head and neck squamous cell carcinoma
AACR Meeting Abstracts 2006 2006: B4. [Abstract]  

Madhabananda Kar, S. V. Surya Narayan Deo, Nootan Kumar Shukla, Uma Sharma, Virendra Kumar, K. A. Danni, Sidharth Datta Gupta, Vaisgali Deo, and Sanjay Thulkar

Metabolic characterization by in vivo proton magnetic resonance spectroscopy (PMRS) - predicts the post treatment status of the soft tissue sarcomas?
AACR Meeting Abstracts 2006 2006: B5. [Abstract]  

Wael M. ElShamy

Acquired-cisplatin resistance by BRCA1-IRIS over-expression in human ovarian epithelial cells
AACR Meeting Abstracts 2006 2006: B6. [Abstract]  

Jacques Medioni, Pascal Leuraud, Jean Yves Delattre, Marie-France Poupon, and Jean-Louis Golmard

New criteria for analyzing the statistical relationships between biological parameters and therapeutic responses of xenografted tumor models
AACR Meeting Abstracts 2006 2006: B7. [Abstract]  

Akihide Ryo, Mayuko Nishi, Kanji Endoh, and Ichiro Aoki

Use of prolyl isomerase Pin1 as a molecular probe to identify cancer-specific phosphorylated proteins
AACR Meeting Abstracts 2006 2006: B8. [Abstract]  

Mayuko Nishi, Ichiro Aoki, and Akihide Ryo

Role of the prolyl-isomerase Pin1 in cap-dependent translation and cell transformation
AACR Meeting Abstracts 2006 2006: B9. [Abstract]  

Pawel Zwolak, Piotr Jasinski, Faris Farassati, Kaoru Terai, Theresia Thalhammer, and Arkadiusz Dudek

Selective protein kinase C-ß inhibitor (Enzastaurin) suppresses tumor growth, bone osteolysis, cancer -induced bone pain, and enhance radiosensitivity of the bone tumor.
AACR Meeting Abstracts 2006 2006: B10. [Abstract]  

Jeffrey R. Jackson, Aidan Gilmartin, Dash Dhanak, Steven Knight, Cindy Parrish, Lusong Luo, David Sutton, Eian Caulder, Melody Diamond, Michele Giardiniere, ShuYun Zhang, Pearl Huang, Gustave Bergnes, Andrew McDonald, Yan Lee, Roman Sakowicz, and Kenneth W. Wood

A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer
AACR Meeting Abstracts 2006 2006: B11. [Abstract]  

Laura A. Meyer, Martin Eiblmaier, Mark A. Watson, Linda J. Pike, Paula M. Fracasso, and Carolyn J. Anderson

In vitro and in vivo interaction of ⁶⁴Cu-DOTA-cetuximab and epidermal growth factor receptor in cervical cancer cell lines
AACR Meeting Abstracts 2006 2006: B12. [Abstract]  

Proffered Abstract (Plenary Session): Successes in Developing Tumor Determinants for Targeted Therapies: Lessons Learned:

Sarah S. Bacus, Patricia Trusk, Ljuba Lyass, Jason E. Hill, and Neil L. Spector

Inhibition of erbB1/2 by small molecule tyrosine kinase inhibitors, but not trastuzumab, affects metabolic pathways: Implications for cardiac toxicity.
AACR Meeting Abstracts 2006 2006: PR-1. [Abstract]  

Erich B. Jaeger, Brian I. Rini, Vivian Weinberg, Nancy Sein, Brooks Bond-Watts, Loretta Chan, Karen Chew, Kristen Fong, Jeffry Simko, Rick Baehner, Eric J. Small, and Frederic M. Waldman

Biomarkers of response to VEGF pathway-targeted therapy for renal cell carcinoma.
AACR Meeting Abstracts 2006 2006: PR-2. [Abstract]  

Diagnostic Technologies and Molecular and Cellular Profiling: Biomarker Assay Development, Validation, and Qualification:

Jin S. Yoo, Christi K. Augustine, Yasunori Yoshimoto, Patricia A. Zipfel, Rebecca P. Petersen, Scott K. Pruitt, Francis Ali-Osman, and Douglas S. Tyler

Predicting temozolomide resistance with MGMT RNA expression in metastatic melanoma
AACR Meeting Abstracts 2006 2006: A2. [Abstract]  

Yan Xiao, Gallya Gannot, Michael R. Emmert-Buck, Sudhir Srivastava, Paul D. Wagner, and Peter E. Barker

Metrology for cancer biomarkers: Affinity analysis of human HER2 and telomerase with IgYs
AACR Meeting Abstracts 2006 2006: A3. [Abstract]  

Olivier Biglia, Marc Essodaigui, Marie Joelle Mozziconacci, Sylvie Hermouet, Fabienne Hermitte, and Nicolas Maroc

Quantitative measurement of JAK2 V617F mutation in myeloproliferative disorders. Validation and qualification of a new RQPCR diagnostic assay.
AACR Meeting Abstracts 2006 2006: A4. [Abstract]  

Robert J. Kinders, Joann Palma, Xuesong Liu, Milagros Colon-Lopez, Yan Luo, Luiz E. Rodriguez, Yan Shi, Ran Guan, Shimin Wei, Jennifer Low, Anthony Murgo, Oxana Pickerel, Shivaani Kumar, Martin Gutierrez, Larry Rubinstein, Sherry Yang, Jay Ji, Gurmeet Kaur, Ralph Parchment, Tiziano DiPaolo, Jerry Collins, Melinda Hollingshead, Joseph Tomaszewski, James Doroshow, and Vincent Giranda

Development of a quantitative enzyme immunoassay for measurement of PAR as a pharmacodynamic biomarker of PARP activity
AACR Meeting Abstracts 2006 2006: A5. [Abstract]  

Irene Baskerville-Abraham, Gunnar Boysen, Esra Mutlu, Stephen G. Chaney, and James A. Swenberg

UPLC-ESI-MS/MS Quantitation of cisplatin 1,2 guanine-guanine intrastrand cross links
AACR Meeting Abstracts 2006 2006: A6. [Abstract]  

Marina C. Garassino, II, Gigliola Montorfano, Sr., Monica Fallini, II, Manuela Adorni, Sr., Bruno Berra, VII, and Angela M. Rizzo, V

A new biomarker in cancer patients: The arachidonic acid/eicosapentaenoic acid (AA/EPA) ratio
AACR Meeting Abstracts 2006 2006: A7. [Abstract]  

Leonid L. Reznikov, Barry Jones, Nazneen Aziz, and Charles A. Dinarello

Talabostat augments IL-1ß and IL-1 production from peripheral blood monocytes isolated from healthy donors.
AACR Meeting Abstracts 2006 2006: A8. [Abstract]  

Hossein A. Ghanbari, Audrey A. Vasauskas, Ilham Bensmail, and Michael S. Lebowitz

HAAH is a serum biomarker for prostate cancer
AACR Meeting Abstracts 2006 2006: A9. [Abstract]  

Alice Wang, Karen Chew, S. Y. Chang, K. Lau, C. Santini, T. Vess, L. Kam-Morgan, M. Eisenberg, J. Bennington, S. Anderson, J. Sninsky, F. Waldman, and J. Hessling

Assessment of hormone receptor status in breast cancer by immunohistochemical and gene expression assays
AACR Meeting Abstracts 2006 2006: A10. [Abstract]  

Helen Wu, Kiran Malhotra, Kavita Lalwani, Rui Li, Janine Cooc, Kathleen D. Danenberg, and Mickey Williams

Multiplex qRT-PCR gene expression assay on the COBAS^® TaqMan 48 Analyzer using RNA extracted from formalin-fixed paraffin embedded tissue
AACR Meeting Abstracts 2006 2006: A11. [Abstract]  

Richard I. Christopherson, Larissa Belov, Stephen P. Mulligan, Nicole Barber, Adrian Woolfson, Mike Scott, Kerryn Stoner, Jeremy S. Chrisp, William A. Sewell, Kenneth F. Bradstock, Linda Bendall, Dana S. Pascovici, Mervyn Thomas, Wendy Erber, Graham AR Young, James S. Wiley, Surender Juneja, William G. Wierda, Anthony R. Green, and Michael J. Keating

Analysis of human leukemias using extensive immunophenotypes from an antibody microarray
AACR Meeting Abstracts 2006 2006: A12. [Abstract]  

Rachel Langland, Thad Sharp, James Tsai, Mickey Williams, and Lin Wu

Development of a companion diagnostic test for inhibitors of V600E BRAF
AACR Meeting Abstracts 2006 2006: A13. [Abstract]  

Beatrice S. Knudsen, April Allen, Dale McLerran, Robert Vessella, Gary McMaster, and Alan Kristal

Branched chain DNA assay for accurate measurement of RNA in formalin-fixed tissues
AACR Meeting Abstracts 2006 2006: A14. [Abstract]  

Kristina Robson, Kim Hamic, Lisa Kivman, Ren Xu, Sid Suggs, and Scott Patterson

Qualification of two multi-plexed immunoassays utilizing meso-scale discovery (MSD) technology for quantitation of angiogenic cytokines used as exploratory biomarkers
AACR Meeting Abstracts 2006 2006: A15. [Abstract]  

Invited Abstract (Keynote Address): Keynote Address:

Yuk Ming Dennis Lo

Molecular detection and monitoring of cancer using tumor-derived DNA in plasma
AACR Meeting Abstracts 2006 2006: KN-02. [Abstract]  

Invited Abstract (Plenary Session): Successes in Developing Tumor Determinants for Targeted Therapies: Lessons Learned:

Manel Esteller

Case history: Lessons learned from the MGMT methylation experience
AACR Meeting Abstracts 2006 2006: PL-03. [Abstract]  

Proffered Abstract (Plenary Session): Germline Determinants of Therapeutic Efficacy and Toxicity:

Rong S. Huang, Shiwei Duan, Wasim K. Bleibel, Wei Zhang, and M. Eileen Dolan

Genes contributing to etoposide-induced cytotoxicity
AACR Meeting Abstracts 2006 2006: PR-3. [Abstract]  

Invited Abstract (Educational Session): Primer on New Frontiers in Diagnostic Technologies:

Martin G. Pomper

Molecular Imaging for Oncology
AACR Meeting Abstracts 2006 2006: ED-05. [Abstract]  

Proffered Abstract (Plenary Session): Monitoring Response During Cancer Therapy:

Evelyn M. McKeegan, Dawn Carlson, Raymond Knight, Milagros Colon-Lopez, Peter Devries, Rod Humerickhouse, and Rick Lesniewski

Characterization of human circulating endothelial cells to monitor response to antitumor therapy in human clinical trials
AACR Meeting Abstracts 2006 2006: PR-5. [Abstract]  

Michael S. Lebowitz, Eva Otahalova, and Hossein A. Ghanbari

A novel biomarker to diagnose and monitor acute myelogenous leukemia
AACR Meeting Abstracts 2006 2006: PR-6. [Abstract]  

Proffered Abstract (Plenary Session): Determinants of Patient Prognosis:

Wolfgang Kemmner and Christian Astrosini

REG1Aand its receptor EXTL3 are prognostic markers in colorectal cancer
AACR Meeting Abstracts 2006 2006: PR-7. [Abstract]  

Loaie Maraqa, M. B. Peter, A. M. Hanby, A. M. Shaaban, D. J. Scott, M. Cummings, K. Horgan, and V. Speirs

CEACAM: A potential novel predictor of breast cancer recurrence
AACR Meeting Abstracts 2006 2006: PR-8. [Abstract]  

Invited Abstract (Plenary Session): The Emerging Impact of Novel Preclinical Models:

Brian D. Ross

Molecular imaging in preclinical and clinical drug development.
AACR Meeting Abstracts 2006 2006: PL-08. [Abstract]  

Richard J. Gilbertson

Stem cells, mice, and men: Integrating human and mouse genomics to advance understanding of the biology and treatment of brain tumors
AACR Meeting Abstracts 2006 2006: PL-09. [Abstract]  

W. David Hankins, P. M. Grimley, W. I. Smith, Jr., D. Zhang, and D. M. Williams

Stratification of likely responders based on individualized kinetic optical response profiling of therapy options in freshly isolated short-term tumor cultures
AACR Meeting Abstracts 2006 2006: PL-11. [Abstract]  

Proffered Abstract (Plenary Session): Predictive Determinants of Tumor Response to Cytotoxic Therapies:

A. R. Frackelton, Jr., L. J. Hafer, D. Turbin, and D. G. Huntsman

Shc proteins predict outcome in treatment-naďve breast cancer patients: Do they also predict chemotherapy benefit?
AACR Meeting Abstracts 2006 2006: PR-9. [Abstract]  

Haiqing Li, Valentina Raia, Francesco Bertolini, and William D. Figg

Circulating endothelial cells as a therapeutic marker for docetaxel treatment and combination therapy of docetaxel and thalidomide in a human prostate cancer model
AACR Meeting Abstracts 2006 2006: PR-10. [Abstract]  

Invited Abstract (Plenary Session): Germline Determinants of Therapeutic Efficacy and Toxicity:

Margaret R. Spitz and Xifeng Wu

An Epidemiologic Approach to Outcome Prediction
AACR Meeting Abstracts 2006 2006: PL-12. [Abstract]  

John Nemunaitis

Individual Determinants of Vaccine Therapy
AACR Meeting Abstracts 2006 2006: PL-14. [Abstract]  

Mark J. Ratain

Case History: The First Drug-Specific FDA-Approved Pharmacogenetic Test: UGT1A1 Genotyping for Irinotecan
AACR Meeting Abstracts 2006 2006: PL-15. [Abstract]  

Preclinical Studies and Early Drug Development: Pharmacology, Pharmacogenetics, and Pharmacogenomics:

Nerea Martínez, Margarita Sánchez-Beato, Paloma de la Cueva, M. Victoria Moneo, Miguel Aracil, Juan Carlos Tercero, José Jimeno, and MiguelAngel Piris

Transcriptional signature associated with response to Aplidin^® (Plitidepsin) in human T-cell lymphoma cell lines
AACR Meeting Abstracts 2006 2006: B13. [Abstract]  

Preclinical Studies and Early Drug Development: Predicting Drug Efficacy and Risk of Adverse Events:

David Campos, Robert Streeper, Mario Sepulveda, Armando Diaz, Michael Wick, David Sidransky, George Demetri, Eric Rowinsky, Enrique Poradosu, Chris Takimoto, and Elzbieta Izbicka

Towards personalized medicine: Evaluation of blood and tissue biomarkers for drug sensitivity in a newly established human xenograft model
AACR Meeting Abstracts 2006 2006: B14. [Abstract]  

Preclinical Studies and Early Drug Development: Predicting Tumor Response to Cytotoxic Therapy:

Cornelia Liedtke, Jens Packeisen, Hartmut Schmidt, Eberhard Korsching, Pia Wuelfing, Burkhard Brandt, Ludwig Kiesel, and Horst Buerger

In vitro chemosensitivity testing in invasive breast cancer: Increased sensitivity of the basal subtype is not independent of the tumor proliferation rate
AACR Meeting Abstracts 2006 2006: B15. [Abstract]  

Ruel Michelin, Lafayette Frederick, Kathleen Lobban, Saroj Pramanik, Roosevelt Shaw, Antony Kinyua, Cynthia Johnson, Henry Lowe, Wolfgang W. Leitner, Ava Joubert, and Arthur Williams

Non-proliferation of MC38 fibrosarcoma cells following in vitro exposure to novel bacillus metabolized lactones
AACR Meeting Abstracts 2006 2006: B16. [Abstract]  

Alexander S. Belokhvostov, Sr., Viktor M. Feniksov, Sr., Konstantin K. Vdovichenko, Sr., and Andrew R. Zaretsky, Sr.

Detection of tumor-derived DNA with EGFR mutations in different biological samples from cancer patients: feasibility and optimization of the method
AACR Meeting Abstracts 2006 2006: B19. [Abstract]  

Rolf J. Craven, Melissa Ranney, and Ikhlas Ahmed

The anti-apoptotic protein clusterin is induced by cancer chemotherapy, stabilized by the proteasome, and degraded by intracellular proteases
AACR Meeting Abstracts 2006 2006: B20. [Abstract]  

Susan H. Wei, Daniel R. Scoles, and Beth Y. Karlan

Predictive efficacy of proapoptotic epigenetic pharmacotherapies: An ovarian cancer paradigm
AACR Meeting Abstracts 2006 2006: B21. [Abstract]  

Ikhlas Ahmed, Melissa Ranney, and Rolf J. Craven

Clusterin is induced by cancer chemotherapy and suppresses histone deacetylase inhibitor-induced apoptosis in breast cancer
AACR Meeting Abstracts 2006 2006: B22. [Abstract]  

Agnes N. Juhasz, Xiwei Wu, Maricela Covarrubias, Frank Yen, Stephen Shibata, and Yun Yen

Gene expression profile in patients' samples with recurrent and persistent squamous cell cancer of head and neck
AACR Meeting Abstracts 2006 2006: B23. [Abstract]  

Diagnostic Technologies and Molecular and Cellular Profiling: Biomarkers in Early Detection and Diagnosis:

Stephanie Lim, Brian L. Schmidt, Maricris Macabeo-Ong, Markus Hardt, Scott E. Dixon, Steven C. Hall, and Richard C.K. Jordan

Psoriasin (S100A7) identified as a biomarker in oral squamous cell carcinoma using a proteomic approach
AACR Meeting Abstracts 2006 2006: A16. [Abstract]  

Sabino Zani, Michiko Momoi, Ji-Hye Paik, Tim Hla, and Wayne A. I. Frederick

Down-regulation of sphingosine 1-phosphate receptor-1 in intestinal tumorigenesis
AACR Meeting Abstracts 2006 2006: A17. [Abstract]  

Maricris Macabeo-Ong, Richard C.K. Jordan, Markus Hardt, Steven Hall, Scott Dixon, Stephanie Lim, and Brian L. Schmidt

Proteomic discovery of markers of metastatic oral SCC
AACR Meeting Abstracts 2006 2006: A19. [Abstract]  

August R. Bauer, Jr.

The dectection of pancreatic cancer from peripheral blood mononuclear cells.
AACR Meeting Abstracts 2006 2006: A20. [Abstract]  

Xin Li, Lingying Zhou, Ying-Hong Feng, Fadi Abdul-Karim, and George Gorodeski

The P2X₇ receptor: A novel biomarker of uterine epithelial cancers
AACR Meeting Abstracts 2006 2006: A21. [Abstract]  

Yasushi Sasaki, Toshihisa Kobayashi, Hiroaki Mita, Minoru Toyota, Hiromu Suzuki, Kohzoh Imai, Yasuhisa Shinomura, and Takashi Tokino

Activation of the ribosomal protein L13 gene in human gastrointestinal cancer
AACR Meeting Abstracts 2006 2006: A22. [Abstract]  

Mohammad Shahid, IV, Mohd. Aslam, III, V. S. Dhillion, V, Mohd. Raish1, Jr., Nida J. Khan, Jr., Rahimunnisa Praveen, Jr., Arif Ahmad, Jr., and Syed Akhtar Husain, VI

Four new novel mutations in SRY (sex determining region) and WT1 (Wilms tumor 1) genes in two sisters with sex reversal and gonadal tumor formation with 46,XY chromosomal constitution.
AACR Meeting Abstracts 2006 2006: A23. [Abstract]  

Lara J. Williams, Laurette Geldenhuys, Nadine M. Vaninetti, Duane L. Guernsey, and Alan G. Casson

Expression of ß-catenin, CDX1 and CDX2 in esophageal adenocarcinoma: association with survival after esophageal resection
AACR Meeting Abstracts 2006 2006: A25. [Abstract]  

D. James Morre, Heather Hignite, Brandon Hostetler, Nicole McClain, Joseph Juang, David Gilmartin, Matthew P. Miner, Michael Iannuzzi, and Dorothy M. Morre

A tNOX-based protocol for early detection of lung cancer in smokers and non-smokers
AACR Meeting Abstracts 2006 2006: A26. [Abstract]  

D. James Morre, Brandon Hostetler, Dorothy M. Morre, and Graham Kelly

tNOX as a serum marker for detection and estimation of tumor burden in prostate cancer
AACR Meeting Abstracts 2006 2006: A27. [Abstract]  

Yong Gu Cho, Jae Hwi Song, Chang Jae Kim, and Won Sang Park

Somatic mutations of the CHOP gene in gastric cancers
AACR Meeting Abstracts 2006 2006: A28. [Abstract]  

Ryung Ah Lee, Eun-Joung Lee, and Eun Jung Ahn

Mass RNA analysis using stool in colorectal cancer
AACR Meeting Abstracts 2006 2006: A29. [Abstract]  

Hye-Sung Moon, Sun Hee Sung, and Hye Young Park

Thymosin ß4 affects the expression of annexin A1 with its signal pathway in cervical cancer cells
AACR Meeting Abstracts 2006 2006: A30. [Abstract]  

Gordana Konjevic, Tatjana Srdic, Sandra Stankovic, Svetislav Jelic, and Momcilo Inic

Constitutive and clinical stage-dependent down-regulation of STAT 1, 3, 4 and 5 expression and induction by Th1 cytokines in breast cancer patients
AACR Meeting Abstracts 2006 2006: A31. [Abstract]  

Mehrdad Mokri, Masoumeh Guity, Siamak Shariat Torbaghan, Mostafa Bagerzade, and Morteza Atri

What is the correlation between Nottingham score and receptor status in malignant breast cancer?
AACR Meeting Abstracts 2006 2006: A32. [Abstract]  

Petra Wilder-Smith, Ani Sarkassian, Joseph Morcos, Daniel Jun, Marie Hammer-Wilson, Diana Messadi, and Tatiana Krasieva

Biomarker expression during oral carcinogenesis using an in vivo imaging approach.
AACR Meeting Abstracts 2006 2006: A33. [Abstract]  

Thomas Litman, Jens Eriksen, Inge M. Svane, Henrik Flyger, and Eva Balslev

MicroRNA profiling of breast cancer using a novel Locked Nucleic Acid (LNA) based microarray
AACR Meeting Abstracts 2006 2006: A34. [Abstract]  

Mark D. Gustavson, Gregory Tedeschi, Robert Camp, and David Rimm

AQUA^TM based analysis of thymidylate synthase (TS) within subcellular compartments reveals a novel biomarker for prediction of survival in colorectal carcinomas.
AACR Meeting Abstracts 2006 2006: A35. [Abstract]  

Michael L. Nickerson, Stan Lilleberg, and Jeffrey A. Durocher

Improved identification of von Hippel-Lindau gene mutations in sporadic kidney tumors by parallel endonuclease scanning and DNA sequencing
AACR Meeting Abstracts 2006 2006: A36. [Abstract]  

Jin Kyung Lee, Young-Joon Hong, Yun Hee Kim, Yoon Hwan Chang, Seok-Il Hong, Woo Chul Noh, and Hye Jin Kang

Evaluation of novel molecular markers for the detection of breast cancer cells in peripheral blood
AACR Meeting Abstracts 2006 2006: A37. [Abstract]  

Els Meulemans, Ernst-Jan Speel, Andrea Rüland, Maria Debiec-Rychter, Raf Sciot, and Patrick Pauwels

Evaluation of MDM2 and CDK4 gene amplification and expression as potential tools for the diagnosis of atypical lipomatous tumors/well-differentiated liposarcomas in paraffin-embedded material
AACR Meeting Abstracts 2006 2006: A38. [Abstract]  

Gyorgy Petrovics, Syed Shaheduzzaman, Bungo Furusato, Albert Dobi, Lakshmi Ravindranath, Christopher Cook, Yongmei Chen, Vasantha Srikantan, Jennifer Cullen, Isabell A. Sesterhenn, David G. McLeod, and Shiv Srivastava

TMPRSS2-ERGfusion transcript has diagnostic and prognostic potential in prostate cancer patients
AACR Meeting Abstracts 2006 2006: A39. [Abstract]  

Animesh Barua, Michael J. Bradaric, Seby L. Edassary, Sameer Sharma, Jacob Rotmensch, Pincas Bitterman, Dale B. Hales, Janice M. Bahr, and Judith L. Luborsky

Anti-tumor antibodies and ovarian cancer in Women and Hens
AACR Meeting Abstracts 2006 2006: A40. [Abstract]  

Chantal Courtemanche, Richard LeBlanc, Lise Gosselin, Marie-Guylaine Gagnon, and Luc Belanger

Detection of JAK2 V617F mutation in patients with myeloproliferative disorders using real-time PCR
AACR Meeting Abstracts 2006 2006: A41. [Abstract]  

Suzanne Miyamoto, Hyun Joo An, Crystal Kirmiz, Bensheng Li, Caroline Chu, Hao Liu, Anthony Ferrige, Robert Alecio, Helen Chew, Gary Leiserowitz, Ralph deVere White, Kit S. Lam, and Carlito B. Lebrilla

The use of glycan serum biomarkers for the detection of cancer
AACR Meeting Abstracts 2006 2006: A42. [Abstract]  

Eric T. Fung

Predicting ovarian cancer among patients with pelvic mass by SELDI multiplexed biomarker assay
AACR Meeting Abstracts 2006 2006: A43. [Abstract]  

Xiaoling Song, Joern Lewin, Fabian Model, Reimo Tetzner, Theo DeVos, Matthias Schuster, Andrew Sledziewski, and Catherine Lofton-Day

Methylation analysis of the promoter region of Septin 9 - a novel biomarker for early detection of colorectal cancer.
AACR Meeting Abstracts 2006 2006: A44. [Abstract]  

Invited Abstract (Plenary Session): Monitoring Response During Cancer Therapy:

Michael Phelps

Overview: Transforming in Vivo Diagnostics into a Molecular Measurement Science.
AACR Meeting Abstracts 2006 2006: PL-19. [Abstract]  

Hadassa Degani

Parametric Diffusion and Perfusion MRI in Monitoring Therapy Response
AACR Meeting Abstracts 2006 2006: PL-20. [Abstract]  

Rebecca Richards-Kortum

Optical Molecular Imaging for in vivo Detection of Dysplasia
AACR Meeting Abstracts 2006 2006: PL-21. [Abstract]  

Preclinical Studies and Early Drug Development: Proof-of-Concept Studies:

Jakob E. Larsen, Jonas R. Henriksen, Margit Bćksted, Thomas L. Andresen, Grete K. Jacobsen, and Kent Jřrgensen

Liposome-based drug delivery using secretory phospholipase A2 as a tumor-specific release mechanism: preclinical evaluation of efficacy, pharmacokinetics, and individual patient expression profiles
AACR Meeting Abstracts 2006 2006: B24. [Abstract]  

Kikuya Kato, Kazuya Taniguchi, Jiro Okami, Ken Kodama, and Masahiko Higashiyama

Intratumor heterogeneity of EGFR mutations in lung cancer tissues and its correlation with the response to gefitinib
AACR Meeting Abstracts 2006 2006: B25. [Abstract]  

Graham R. Robertson, Marina Kacevska, Rohini Sharma, Andre Mahns, Chris Liddle, and Stephen Clarke

Impact of inflammation on drug clearance pathways in cancer: Repression of hepatic CYP3A and drug transporter genes by tumor-derived cytokines
AACR Meeting Abstracts 2006 2006: B26. [Abstract]  

Aguilera A. Todd, Emilia S. Olson, Tao Jiang, Ed H. Wong, Quyen Nguyen, Mariam Scadeng, Lesley Ellies, and Roger Y. Tsien

Tumor imaging and therapy with activatable cell penetrating peptides
AACR Meeting Abstracts 2006 2006: B27. [Abstract]  

Invited Abstract (Plenary Session): Regulatory Integration of Diagnostic Markers and Therapeutic Trials:

Keith Baggerly

Pitfalls in Experimental Design and Data Analysis
AACR Meeting Abstracts 2006 2006: PL-26. [Abstract]  

Richard M. Simon

Moving from Correlative Studies to Predictive Medicine: How to Include Biomarkers in Clinical Trials
AACR Meeting Abstracts 2006 2006: PL-27. [Abstract]  

Preclinical Studies and Early Drug Development: Target Identification, Validation, Lead Discovery, and Optimization:

Teresa Puig, Alejandro Vázquez-Martín, Pedro Marrero, Gemma Casals, Jordi Pétriz, Joana Relat, Diego Haro, Javier A. Menéndez, María Luz López-Rodríguez, Maria Vilanova, and Ramon Colomer

Fatty acid metabolism in cancer cells: Differential inhibitory effects of epigallocatechin (EGCG) and C75
AACR Meeting Abstracts 2006 2006: B28. [Abstract]  

Wei Li, Ningxi Zhu, Qian Wang, Timothy P. Fleming, and Shaojin You

Mammaglobin: a specific molecular target for immune based breast cancer therapy
AACR Meeting Abstracts 2006 2006: B30. [Abstract]  

Hideyuki Yoshitomi, Shigeaki Takano, Kazuyuki Sogawa, Fumio Kimura, Hiroaki Shimizu, Hiroyuki Yoshidome, Masayuki Otsuka, Takeshi Tomonaga, Fumio Nomura, and Masaru Miyazaki

Expression of apolipoprotein C-1 in pancreatic cancer and its role in cell survival by avoiding apoptotic cell death
AACR Meeting Abstracts 2006 2006: B31. [Abstract]  

Jefferson Terry and Torsten O. Nielsen

17-allylamino-17-demethoxygeldanamycin disrupts SYT-SSX-ß-catenin interaction in synovial sarcoma
AACR Meeting Abstracts 2006 2006: B32. [Abstract]  

Konstantin Christov, Clinton Grubbs, Vernon Steele, and Ronald Lubet

Early biomarkers of response of mammary tumors to preventive/therapeutic agents
AACR Meeting Abstracts 2006 2006: B33. [Abstract]  

Thorsten Schlomm, Andreas Erbersdobler, Olaf JC Hellwinkel, Hartwig Huland, Ronald Simon, and Guido Sauter

Clinical significance of EGFR and HER2 overexpression in prostate cancer
AACR Meeting Abstracts 2006 2006: B34. [Abstract]  

MyDoanh Chau, Yoko Otake, Jennifer L. Christensen, Daniel J. Fernandes, and Alfred M. Ajami

The imidazoacridinone, C-1311 (Symadex^TM): The first of a potent new class of FLT3 inhibitors
AACR Meeting Abstracts 2006 2006: B35. [Abstract]  

Subhash C. Chauhan, Namita Vinayek, Katrina Dunham, Yuhlong Lio, Michael D. Koch, and Meena Jaggi

Analysis of MUC1, MUC 16 and TAG 72 expression in ovarian cancer: Antigens for multi-targeted antibody guided therapy
AACR Meeting Abstracts 2006 2006: B36. [Abstract]  

Ginette Serrero, Jiangping Dong, Leslie Jones, Joseph Corvera, Randall Barton, and Binbin Yue

GP88 (PCDGF, granulin-epithelin precursor) and chemoresistance in breast cancer
AACR Meeting Abstracts 2006 2006: B37. [Abstract]  

Chang Xu, Lynn F. Graf, Ladan Fazli, Peter S. Nelson, Stephen R. Plymate, Michael E. Cox, Beverly J. Torok-Storb, and Beatrice S. Knudsen

IGFBP-5 in the bone and bone marrow is a therapeutic target for metastatic prostate cancer
AACR Meeting Abstracts 2006 2006: B38. [Abstract]  

John Nemunaitis, Neil Senzer, Jerry Shen, Phillip Maples, Donald Rao, Alex Tong, Padmasini Kumar, Joe Kuhn, Yu-An Zhang, Jian Liao, Iya Khalil, Colin Hill, and Adi Gazdar

Clinical study of personalized therapeutics based on genomic/proteomic profiling
AACR Meeting Abstracts 2006 2006: A118. [Abstract]  

Invited Abstract (Plenary Session): Determination of Clinicially Effective Dose and Schedule:

Zvia Agur, Irit Ziv, Revital Shochat, Michael Wick, Craig Webb, David Hankins, Levon Arakelyan, and David Sidransky

Using a Novel Computer Technology for Tailoring Targeted and Chemotherapeutic Drug Schedules to the Individual Patient
AACR Meeting Abstracts 2006 2006: PL-29. [Abstract]  

David A. Mankoff, Hannah M. Linden, Jeanne M. Link, William E. Barlow, and Kenneth A. Krohn

Molecular Imaging to Guide Targeted Therapy
AACR Meeting Abstracts 2006 2006: PL-31. [Abstract]  

Paul Workman

Drugging the cancer genome: Advances, challenges, and the pharmacologic audit trail
AACR Meeting Abstracts 2006 2006: PL-32. [Abstract]  

Invited Abstract (Plenary Session): Determinants of Patient Prognosis:

George Adrian Calin

Molecular Diagnostics in Cancer Therapeutic Development: Maximizing Opportunities for Individualized Treatment
AACR Meeting Abstracts 2006 2006: PL-34. [Abstract]  

Laura J. van 't Veer

Molecular Profiles Guide the Way to Improve Patient Management
AACR Meeting Abstracts 2006 2006: PL-36. [Abstract]  

Preclinical Studies and Early Drug Development: Other Preclinical Studies:

Keishi Narita, Jeremy Chien, Sally A. Mullany, Julie K. Staub, Xiang Qian, and Viji Shridhar

Downregulation of HSulf-1 promotes autocrine signaling in breast cancer
AACR Meeting Abstracts 2006 2006: B39. [Abstract]  

Valery M. Nelson, Angela H. Finney, Robert J. Drape, Gregory T. Bleck, Michael S. Lebowitz, and Hossein A. Ghanbari

Manufacture of anti-HAAH antibodies as potential human therapeutics
AACR Meeting Abstracts 2006 2006: B40. [Abstract]  

Invited Abstract (Plenary Session): Predictive Determinants of Tumor Response to Cytotoxic Therapies:

Michael S. O'Reilly

Measuring response to antiangiogenic agents
AACR Meeting Abstracts 2006 2006: PL-40. [Abstract]  

Gennadi V. Glinsky

The Rosetta stone of oncogenomics: From genetic signatures of prostate and breast stem cell cancers as molecular markers of cancer treatment outcome (CTO) to individualized target-tailored cancer therapies
AACR Meeting Abstracts 2006 2006: PL-41. [Abstract]  

Targeted Therapies and Clinical Translational Research: Clinical Pharmacology, Pharmacogenetics, and Pharmacogenomics:

Kenji Okumura, Eiji Mekata, Hisanori Shiomi, Yoshihiro Endo, Yoshimasa Kurumi, and Tohru Tani

Thymidylate synthase is a predictor of chemosensitivity to different 5-fluorouracil regimens in primary colorectal cancer.
AACR Meeting Abstracts 2006 2006: B41. [Abstract]  

Christina Justenhoven, Malgorzata Jaremko, Werner Schroth, Benny K. Abraham, Peter Fritz, Caren Vollmert, Thomas Illig, Wolfgang Simon, Matthias Schwab, and Hiltrud B. Brauch

A polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and CMF-based chemotherapy of patients with primary invasive breast cancer
AACR Meeting Abstracts 2006 2006: B42. [Abstract]  

Werner Schroth, Lydia Antoniadou, Peter Fritz, and Hiltrud Brauch

A retrospective study of breast cancer patients with adjuvant tamoxifen and/or chemotherapy for the analyses of candidate genetic markers and their possible association with treatment outcomes
AACR Meeting Abstracts 2006 2006: B43. [Abstract]  

Targeted Therapies and Clinical Translational Research: Clinical Trial Methodology/Design:

John D. Roberts and V. Ramakrishnan

Phase II trials powered to detect tumor subsets through the application of predictive markers.
AACR Meeting Abstracts 2006 2006: B44. [Abstract]  

John L. Tedesco, William Goeckeler, John G. Wolodzko, and Michael Becker

Development of optimal Lu-177 labeled monoclonal antibody (7E11) constructs (CYT-500) for radioimmunotherapy of hormone refractory prostate cancer
AACR Meeting Abstracts 2006 2006: B45. [Abstract]  

Diagnostic Technologies and Molecular and Cellular Profiling: Detection of Circulating Tumor Cells or Endothelial Cells/Progenitors:

Winfried H. Albert, Veit Zieglschmid, Silke Zimmermann, and Oliver Böcher

Detection and molecular profiling of circulating tumor cells
AACR Meeting Abstracts 2006 2006: A46. [Abstract]  

Kiyomi Taniyama, Kazuya Kuraoka, Junichi Sakane, Kyoko Makita, Yasumasa Akai, Motonari Daito, Yasuhiro Otomo, Masanobu Shigeta, Tomoya Mizunoe, Yukiyasu Takeuchi, Harumi Tominaga, and Masato Koseki

Combinational analysis of a whole lymph node by OSNA and histology for intra-operative detection of micro-metastases
AACR Meeting Abstracts 2006 2006: A47. [Abstract]  

Hisae Iinuma, Toshiaki Watanabe, Keiji Matsuda, Toshiki Mimura, Keijirou Nozawa, Junko Tamura, Satoru Ohnaka, Toshinori Hayashi, Kota Okinaga, and Tadahiro Takada

A novel intra-operative genetic predictive diagnosis for peritoneal recurrence in colorectal cancer patients
AACR Meeting Abstracts 2006 2006: A48. [Abstract]  

Evelyn M. McKeegan, Daniel Albert, Paul Tapang, Terry Magoc, Cherrie Donawho, Amanda Niquette, Jason Stavropoulos, Laura McKay, Abdullah Kherzai, Jack Henkin, Nancy Xie, and Rick Lesniewski

Circulating endothelial cells in preclinical models of cancer
AACR Meeting Abstracts 2006 2006: A49. [Abstract]  

Fang Jiang, Charles Van Sant, Mary Saltarelli, Milagros Colon-Lopez, Rick Lesniewski, and Evelyn M. McKeegan

Early exploration of circulating tumor cells (CTC) as a predictive biomarker for cancer treatment response
AACR Meeting Abstracts 2006 2006: A50. [Abstract]  

Eugeny Arons, Joel Sunshine, Tara Suntum, Inger Margulies, Lynn Sorbara, Mark Raffeld, Maryalice Stetler-Stevenson, Ira Pastan, and Robert J. Kreitman

Minimal residual disease in hairy cell leukemia patients treated by BL22
AACR Meeting Abstracts 2006 2006: A51. [Abstract]  

Targeted Therapies and Clinical Translational Research: Combination Therapies:

Dmytro M. Havaleshko, HyungJun Cho, Jae K. Lee, Garret Hampton, and Dan Theodorescu

Cancer chemosensitivity prediction of drug combinations using single drug responses and microarray profiling data
AACR Meeting Abstracts 2006 2006: B46. [Abstract]  

Philip M. Grimley, William I. Smith, Donna Williams, Zhang Li, and W. David Hankins

Real time monitoring of cytotoxicity in selection of agents for treatment of refractory malignancy
AACR Meeting Abstracts 2006 2006: B47. [Abstract]  

Andres Soriano, Hui Yang, Srdan Verstovsek, William Wierda, Charles Koller, Zeev Estrov, Souzanne Ouzounian, Hagop Kantarjian, Jean Pierre Issa, and Guillermo Garcia-Manero

5-azacytidine(5- AC), all-trans retinoic acid (ATRA), and valproic acid (VPA) in patients with acute myelogenous leukemia (AML): Molecular and clinical implications
AACR Meeting Abstracts 2006 2006: B48. [Abstract]  

Carolyn B. Howard, Ernest B. Izevbigie, and Michael M. Opata

Inhibition of paclitaxel-resistant MCF-7 RAg cell growth by Vernonia amygdalina extract
AACR Meeting Abstracts 2006 2006: B49. [Abstract]  

Anne Nguyen, Jefferson Terry, Suzanne Liu, and Torsten O. Nielsen

Hsp90 and histone deactylase inhibitor have synergistic activity against synovial sarcoma.
AACR Meeting Abstracts 2006 2006: B50. [Abstract]  

Scott Kopetz, Ji Wu, Faye Johnson, and Nicholas Donato

Anti-tumor effects of combination therapy with anti-EGFR and anti-Src therapy in colorectal cancer
AACR Meeting Abstracts 2006 2006: B51. [Abstract]  

Diagnostic Technologies and Molecular and Cellular Profiling: Determinants of Patient Prognosis:

Yixin Wang, John Jiang, Conor Delaney, Ian Lavery, Yi Zhang, Michelle McGreevy, Dmitri Talantov, Dondapati Chowdary, Marek Skacel, Elena Manilich, Abhijit Mazumder, David Atkins, and Graham Casey

Development of a molecular assay on FFPE samples to predict recurrence of stage II colon cancer
AACR Meeting Abstracts 2006 2006: A52. [Abstract]  

Caroline Wood, Hartley Stern, Maha Guindi, and Alain E. Lagarde

Molecular detection of lymph node micrometastases in colorectal cancer patients
AACR Meeting Abstracts 2006 2006: A53. [Abstract]  

Qi He, Dongyuan Liu, Jinghe Lang, and Jing Jie Yu

Vascular growth factor expression in endometrial carcinoma in relation to angiogenesis and FIGO grade
AACR Meeting Abstracts 2006 2006: A54. [Abstract]  

Shigetsugu Takano, Hideyuki Yoshitomi, Kazuyuki Sogawa, Fumio Kimura, Hiroaki Shimizu, Hiroyuki Yoshidome, Masayuki Otsuka, Takeshi Tomonaga, Fumio Nomura, and Masaru Miyazaki

Identification of apolipoprotein C-1 as a novel prognostic serum marker of pancreatic cancer and its expression in cancer cells
AACR Meeting Abstracts 2006 2006: A55. [Abstract]  

Stephen Little, Nicola Thelwell, Paul Ravetto, and David Whitcombe

Development of a diagnostic test for mutations in the EGFR gene
AACR Meeting Abstracts 2006 2006: A56. [Abstract]  

Sing F. Leung, Benny Zee, Brigette B. Ma, Edwin P. Hui, Frankie Mo, Maria Lai, K. C. Allen Chan, Lisa YS Chan, Wing Hong Kwan, Y. M. Lo, and Anthony TC Chan

Peripheral-blood cell-free Epstein-Barr viral DNA load complements clinical staging in nasopharyngeal carcinoma prognostication
AACR Meeting Abstracts 2006 2006: A57. [Abstract]  

Andre T. Baron, Jessica N. McAlpine, Jason Wilken, Mi-Ok Kim, Kimberly Kimbler, Trace Christensen, Wenxin Zheng, Maritza Martel, Fattaneh A. Tavassoli, and Nita J. Maihle

Profiling EGFR isoforms in ovarian cancer demonstrates that EGFR and sEGFR have prognostic significance: Implications for EGFR isoforms as cancer biomarkers.
AACR Meeting Abstracts 2006 2006: A58. [Abstract]  

Miho Takao, Aikou Okamoto, Takashi Nikaido, Mitsuyoshi Urashima, Sanshiro Okamoto, Kazunori Ochiai, and Tadao Tanaka

Clinical significance of IDO (Indoleamine-2, 3-dioxygenase), nuclear factor-kB (NFkB) and Akt2 expression in various pathological types of ovarian cancers
AACR Meeting Abstracts 2006 2006: A59. [Abstract]  

Lionel Coignet, Christiane Houde, Jean Dolce, Brian Bundy, Mary Nesline, Christine Ambrosone, William McLaughlin, and Donald Trump

The presence of the FRA12E/SMRT fragile site in the genome of prostate cancer patients is a predictor of metastatic development
AACR Meeting Abstracts 2006 2006: A60. [Abstract]  

Els Meulemans, Ernst-Jan M. Speel, Georges PH Lucker, David Creytens, Adrienne Van Geest, Ton Vermeulen, Sandra Claessen, and Patrick Pauwels

Differences in Imiquimod treatment outcome in two patients with Bowenoid Papulosis containing either episomal or integrated HPV 16.
AACR Meeting Abstracts 2006 2006: A61. [Abstract]  

Cristina M.M. Campofiorito, Flavia R.R. Mangone, Fátima S. Pasini, Simone Maistro, Karen C.S. Brunialti, Igor M.L. Snitcovsky, Carlos N. Lehn, Fernando Walder, Marcos B. Carvalho, Mitzi Brentani, and Miriam H. Federico

CCR7/CCL21 receptor ligand system may play a role in the lymph node metastasis of oral squamous cell carcinoma
AACR Meeting Abstracts 2006 2006: A62. [Abstract]  

Keith A. Dookeran, X. Gao, Y. Wang, K. Ferrer, M. Sekosan, B. Lukaszczyk, G. Roman, R. De La Torre, A. Jacobson, E. K. Radeke, T. Mackevicius, H. A. Zaren, and W. McCaskill-Stevens

p53 status is more likely than basal subtype to predict survival in African-American women with breast cancer
AACR Meeting Abstracts 2006 2006: A63. [Abstract]  

Targeted Therapies and Clinical Translational Research: Determinants of Recurrence, Survival, and Response to Treatment:

Laura L. Licato, Kerstin Menander, Robert E. Sobol, Louis A. Zumstein, Martha French, Dora Bocangel, Jack Roth, and Sunil Chada

Abnormal overexpression of p53 is a predictive molecular biomarker of Advexin (adenoviral p53) efficacy in recurrent squamous cell carcinoma of the head and neck (SCCHN)
AACR Meeting Abstracts 2006 2006: B52. [Abstract]  

Matthew W. Beer, Christopher Ung, Janice Spohn, Karen Pry, and Sarah S. Bacus

Immunohistochemical (IHC) assessment of transforming growth factor alpha (TGF-) in conjunction with epidermal growth factor receptor (EGFR) as potential determinants of response to EGFR-targeted therapy in patients with advanced colorectal cancer (C
AACR Meeting Abstracts 2006 2006: B53. [Abstract]  

Lun-Xiu Qin, Jin-Zhong Pang, Ning Ren, Qing-Hai Ye, and Zhao-You Tang

The roles of loss of heterozygosity at 8p22 in the molecular classification of patients with hepatocellular carcinoma, with special reference to survival after surgical operation
AACR Meeting Abstracts 2006 2006: B54. [Abstract]  

Lun-Xiu Qin, Hong-Hai Wang, Hui Zhang, Qing-Hai Ye, Ning Ren, and Zhao-You Tang

The predictive values of combined assessment of preoperative plasma levels of OPN and ICAM-1 for prognosis of patients with hepatocellular carcinoma:retrospective and prospective validations
AACR Meeting Abstracts 2006 2006: B55. [Abstract]  

Michael C. Heinrich, Robert G. Maki, Christopher L. Corless, Cristina R. Antonescu, Jonathan A. Fletcher, Christopher D. Fletcher, Xin Huang, Charles M. Baum, and George D. Demetri

Correlation of KIT and PDGFRA mutation status with sunitinib activity in imatinib-resistant GIST
AACR Meeting Abstracts 2006 2006: B56. [Abstract]  

William P. Worzel, Craig C. Webb, Arpit Almal, Jeremy Miller, David W. Fry, and Peter F. Lenehan

Genetic programming analysis of gene expression profiles predicts survival in pleural mesothelioma.
AACR Meeting Abstracts 2006 2006: B57. [Abstract]  

Targeted Therapies and Clinical Translational Research: Drug Sensitivity and Resistance:

Nesrin S. Rechache, Rebecca Riggins, Alan Zwart, and Robert Clarke

Molecular mechanisms of taxane resistance
AACR Meeting Abstracts 2006 2006: B58. [Abstract]  

Shai White, Laura Kasman, Laura Spruill, Paul McDermott, and Christina Voelkel-Johnson

TRAIL sensitization of PC3 prostate cancer cells by doxorubicin can be blocked by the anti-oxidant N-acetyl-cysteine or by the iron chelator deferoxamine
AACR Meeting Abstracts 2006 2006: B59. [Abstract]  

Deric L. Wheeler, Tim J. Kruser, Shymin Huang, Vinai Gondi, Eric A. Armstrong, and Paul M. Harari

Development and characterization of EGFR inhibitor resistant lines; A model to study acquired resistance to EGFR blockade
AACR Meeting Abstracts 2006 2006: B60. [Abstract]  

Hiroyasu Yasuda, Katsutoshi Nakayama, Mika Watanabe, Satoshi Suzuki, Tomohiro Kaneta, Masanori Asada, Yoshihiro Takai, Shoji Okinaga, Akio Kanda, Kazuhiro Yanagihara, and Mutsuo Yamaya

Nitroglycerin treatment may increase response to docetaxel and carboplatin regimen via inhibitions of hypoxia-inducible factor-1 pathway and P-glycoprotein in patients with lung adenocarcinoma
AACR Meeting Abstracts 2006 2006: B61. [Abstract]  

Manfred Dietel, Carsten Denkert, Jan Budczies, Balázs Györffy, and Hermann Lage

DNA-microarrays predicting chemotherapy response of ovarian carcinomas
AACR Meeting Abstracts 2006 2006: B62. [Abstract]  

Marleen Gosens, Elna Moerland, Valery Lemmens, Harm Rutten, Ivonne Tan-Go, and Adriaan van den Brule

The thymidylate synthase variable number of tandem repeats polymophism is predictive for response to 5-fluoracil in patients with colon cancer
AACR Meeting Abstracts 2006 2006: B63. [Abstract]  

Ian A. Cree, Sharon Glaysher, Louise A. Knight, Francis G. Gabriel, Paul Modi, Dennis Yiannakis, Joe Rahamin, Mark Smith, Khalid Amer, Bruce Addis, Peter John Davies, and Peter E. Andreotti

The molecular basis of chemosensitivity of non-small cell lung cancer (NSCLC) to cisplatin and docetaxel.
AACR Meeting Abstracts 2006 2006: B64. [Abstract]  

John S. Coon, Larry Morrison, Kris Jacobson, Susan Jewell, Meryl Gale, Victoria Villaflor, Ann Mauer, Tariq Muzzafar, Lela Buckingham, and Philip Bonomi

Chromosome 7 polysomy and biomarker combinations as potential predictors of gefitinib efficacy in non-small cell lung cancer (NSCLC).
AACR Meeting Abstracts 2006 2006: B65. [Abstract]  

Stuart Thomson, Filippo Petti, Elizabeth Buck, Sharon Barr, Alexandra Eyzaguirre, Gina Sennello, David Young, Ken Iwata, Pablo Cagnoni, Neil Gibson, and John D. Haley

Proteomic and IHC measurements of cellular sensitivity to EGF receptor kinase inhibitors
AACR Meeting Abstracts 2006 2006: B66. [Abstract]  

Nelmary Hernandez Alvarado, Jeremy Chien, and Viji Shridhar

Functional DNA J domain is required for methylation-controlled J protein (MCJ/DNAJC15)-mediated chemosensitivity
AACR Meeting Abstracts 2006 2006: B67. [Abstract]  

Michael C. Heinrich, Jason R. Morich, Emmanuel J. Beillard, Courtney Fuller, Chad D. Galderisi, and Brian J. Druker

A novel, high-throughput assay for detection of ABL T315I mutations
AACR Meeting Abstracts 2006 2006: B68. [Abstract]  

G. Huber, T. Roten, V. Brondani, F. Hamy, D. Heim, T. Klimkait, and Vincent Vidal

A phenotypic assay to monitor therapeutic efficacy of signal transduction inhibitors
AACR Meeting Abstracts 2006 2006: B69. [Abstract]  

Daniah Thompson, Jeremy Chien, Julie Staub, Julian Molina, and Viji Shridhar

Loss of HtrA3, a serine protease involved in smoking-related lung cancer: Implications for chemoresistance
AACR Meeting Abstracts 2006 2006: B70. [Abstract]  

Diagnostic Technologies and Molecular and Cellular Profiling: Functional and Molecular Imaging In Vivo and In Vitro:

Zhang Zhenwei, Gu Jinfa, Zhao Ming, Wu Hua, Zhiqun Xianyu, Zhang Xuemei, and Liu Xinyuan

Two birds, one stone: Imaging gene transfer and enhancing TRAIL-induced antitumor efficacy using oncolytic adenovirus bearing human somatostatin receptor subtype 2 gene
AACR Meeting Abstracts 2006 2006: A64. [Abstract]  

Kristen E. Adams, Shi Ke, Sunkuk Kwon, Feng Liang, Zhen Fan, Yang Lu, Karen Hirshi, Michel E. Mawad, Michael A. Barry, and Eva M. Sevick-Muraca

Influence of NIR and red fluorescent wavelengths on animal imaging and biological effects of targeting molecules on cancer cells
AACR Meeting Abstracts 2006 2006: A65. [Abstract]  

Joerg Schwock, James C. Ho, Ed Luther, David Hedley, and William R. Geddie

Detection and measurement of phosphorylated signaling proteins in solid tumor fine-needle biopsies by laser-scanning cytometry
AACR Meeting Abstracts 2006 2006: A66. [Abstract]  

Zahia Ichalalčne, Joe Kozikowski, Salim Djeziri, Samira Mezziani, Frédéric Leblond, Niculae Mincu, and Mario Khayat

Functional oxyhemoglobin and scattering indices for in-vivo characterization of breast cancer
AACR Meeting Abstracts 2006 2006: A67. [Abstract]  

Cliff Murray, Josephine Bunch, Jaume Seuma, Alan Cox, Jackie Rodgers, and Cameron McLeod

Imaging via LA-ICP-MS: assessing cancer biomarkers
AACR Meeting Abstracts 2006 2006: A68. [Abstract]  

Ruchi Sharma, John Rasmussen, Jessica P. Houston, Kristen Adams, Shi Ke, Sunkuk Kwon, Eva M. Sevick, Colleen Nycz, Ronald J. Pettis, and Diane Sutter

Dynamic lymph node mapping using a near infrared fluorescent dye
AACR Meeting Abstracts 2006 2006: A69. [Abstract]  

Buck E. Rogers, Thomas S. Kelly, Rebecca Andrews, and Jesse J. Parry

Development of radiolabeled bombesin analogs for the detection of gastrin-releasing peptide receptor expressing prostate cancer
AACR Meeting Abstracts 2006 2006: A70. [Abstract]  

Diagnostic Technologies and Molecular and Cellular Profiling: Genomics-Expression Profiling in Tumors and Model Systems:

Sudip Sen, Bushra Ateeq, Himani Sharma, Palika Datta, Siddhartha Datta Gupta, Sabyasachi Bal, Arvind Kumar, and Neeta Singh

Identification of differentially expressed genes in human lung squamous cell carcinoma in Asian Indians using suppression subtractive hybridization
AACR Meeting Abstracts 2006 2006: A71. [Abstract]  

Heike Weber, Umesh Bhanot, Hans Kestler, Holger Kohlhammer, Swen Wessendorf, Carsten Schwaenen, Hartmut Döhner, Thomas M. Gress, and Karlheinz Holzmann

Use of genomic DNA-chip hybridizations (matrix-CGH/array-CGH) for detection of novel genetic alterations in pancreatic carcinomas
AACR Meeting Abstracts 2006 2006: A72. [Abstract]  

Tzu-Hao H. Wang, Shiaw-Min M. Hwang, Kuan-Den D. Chen, Yun-Shien S. Lee, and Hsin-Shih S. Wang

Comparison of transcriptomes of mesenchymal stem cell lines derived from amniotic fluid, amniotic membrane, cord blood, and bone marrow
AACR Meeting Abstracts 2006 2006: A73. [Abstract]  

Akitake Mukasa, Julie Steele, Lynda Chin, Webster K. K. Cavenee, and Frank Furnari

The role of EGFR* signaling pathway for tumor maintenance and alternative pathways in glioblastoma which enhance tumor growth
AACR Meeting Abstracts 2006 2006: A74. [Abstract]  

Lorraine O'Driscoll, Elaine Kenny, and Martin Clynes

Analysis of extracellular gene transcripts from cancer cells using whole genome microarrays
AACR Meeting Abstracts 2006 2006: A75. [Abstract]  

Nijaguna B. Prasad, Yongchun Wang, Christopher B. Umbricht, Steven K. Libutti, and Martha A. Zeiger

Molecular signatures of eight thyroid tumor types
AACR Meeting Abstracts 2006 2006: A76. [Abstract]  

J. W. Harbour

Molecular prediction of time to metastasis from ocular melanoma fine needle aspirates
AACR Meeting Abstracts 2006 2006: A77. [Abstract]  

Anya Tsalenko, Mona Prasad, Jana Paderova, Paula Marrano, Chung-Hae Lee, Zohar Yakhini, Amir Ben-Dor, Jeremy Squire, and Michael Barrett

Combined cytogenetic, aCGH and gene expression analysis of cisplatin resistant ovarian cancer cells
AACR Meeting Abstracts 2006 2006: A78. [Abstract]  

Zhiyuan Hu, He Xiaping, Matthew Ewend, and Charles M. Perou

Predictions of breast cancer local and distant metastasis
AACR Meeting Abstracts 2006 2006: A79. [Abstract]  

Jongwook Kim, Anil Potti, and Joseph R. Nevins

microRNA and mRNA expression signatures of Myc and E2F1 oncogenic pathways
AACR Meeting Abstracts 2006 2006: A80. [Abstract]  

Benita Tan, Lay Kar Tan, Kun Yu, Khee Chee Soo, Chow Yin Wong, Allen Yeo, Gay Hui Ho, Neng Hung Koong, Wei Sean Yong, Karen Yap, Puay Hoon Tan, and Patrick B. Tan

Clinical validation of breast cancer gene expression signatures using customized microarrays
AACR Meeting Abstracts 2006 2006: A81. [Abstract]  

Frédérique Végran, Romain Boidot, Pierre Fumoleau, Lyse Hahnel, Muriel Cadouot, and Sarab Lizard-Nacol, Jr.

• >Expression profile of apoptosis genes in breast tumors over expressing survivin.
AACR Meeting Abstracts 2006 2006: A82. [Abstract]  

Romain Boidot, Frédérique Végran, Muriel Cadouot, Lyse Hahnel, Pierre Fumoleau, and Sarab Lizard-Nacol, Jr.

• >Gene expression changes after one course of chemotherapy in breast cancer
AACR Meeting Abstracts 2006 2006: A83. [Abstract]  

Martin Anne-Marie, Kay Tatsuoka, Michal Magid-Slav, Patrick Warren, Kathleen Danenberg, and Tal Z. Zaks

Epidermal growth factor receptor (EGFR) gene and protein expression in renal cell carcinoma (RCC)
AACR Meeting Abstracts 2006 2006: A84. [Abstract]  

Saskia Cillessen, Corine Hess, Erik Hooijberg, Kitty Castricum, Pim Kortman, Fedor Denkers, Wim Vos, Gerrit-Jan Schuurhuis, Gert Ossenkoppele, Chris Meijer, and Joost Oudejans

Apoptosis profiling in diffuse large B-cell lymphomas for tailoring of therapy.
AACR Meeting Abstracts 2006 2006: A85. [Abstract]  

Charles Van Sant, Gang Wang, Mark Anderson, Rick Lesniewski, and Dimitri Semizarov

Endothelin signaling in osteoblastic metastases: molecular mechanisms and biomarkers
AACR Meeting Abstracts 2006 2006: A86. [Abstract]  

Yu-Tsueng Liu and Dennis A. Carson

Isolation of cancer-specific CDKN2A breakpoint fusion sequences in the presence of contaminating normal DNA
AACR Meeting Abstracts 2006 2006: A87. [Abstract]  

Alain Barrier, Antoinette Lemoine, Pierre-Yves Boelle, Antoine Flahault, and Sandrine Dudoit

Stage III colon cancer prognosis prediction by tumor gene expression profiling
AACR Meeting Abstracts 2006 2006: A88. [Abstract]  

Zvi Bentwich

MicroRNA expression as a powerful diagnostic tool in cancer
AACR Meeting Abstracts 2006 2006: A89. [Abstract]  

Douglas T. Ross, Brian Z. Ring, Noel Estopinal, Marshall Schroeder, David Hicks, and Robert S. Seitz

Translation of gene expression profiles into a novel immunohistochemistry based classification of carcinoma
AACR Meeting Abstracts 2006 2006: A90. [Abstract]  

Targeted Therapies and Clinical Translational Research: Molecular Endpoints in Clinical Trials:

Karoline E. Horisberger, Benjamin Muessle, Ralf D. Hofheinz, Pablo Palma, Andreas Hochhaus, Stefan Post, and Frank Willeke

• >Expression of topoisomerase I in rectum cancer patients in correlation to response to irinotecan-based chemoradiation
AACR Meeting Abstracts 2006 2006: B71. [Abstract]  

Virginia Espina, Benedetta Accordi, Robyn Araujo, Brieanne Midura, Choh Yeung, Xiaolin Wan, Gabriel S. Eichler, Donald J. Johann, Jr., William Meyer, Stephen Qualman, James R. Anderson, Seth M. Steinberg, Maria Tsokos, Kartik Krishnan, Emanuel F. Petricoin, III, Lee J. Helman, and Lance A. Liotta

Phosphoprotein pathway mapping: AKT/mTOR activation is negatively associated with childhood Rhabdomyosarcoma survival
AACR Meeting Abstracts 2006 2006: B72. [Abstract]  

Paul Workman, Hayley Farmer, Eric O. Aboagye, Yuen L. Chung, John R. Griffiths, Rachel Hart, Martin O. Leach, Ross J. Maxwell, Paul M. McSheehy, Pat M. Price, and Jamal Zweit

Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies: experience and recommendations
AACR Meeting Abstracts 2006 2006: B73. [Abstract]  

Jordi Rodon, Andrew Hsu, Chris Takimoto, Robert Geller, and Anthony Tolcher

Development of biomarkers in Phase I trials of targeted therapies: The reality of the clinical research forefront
AACR Meeting Abstracts 2006 2006: B74. [Abstract]  

Targeted Therapies and Clinical Translational Research: Monitoring Response to Therapy:

Stig T. Linder, Takayuki Ueno, Aleksandra M. Havelka, Maria Hägg Olofsson, Maria C. Shoshan, Gero Kramer, and Masakazu Toi

Measuring tumor cell apoptosis and necrosis in serum of cancer patients during therapy
AACR Meeting Abstracts 2006 2006: B75. [Abstract]  

Andriy Babsky, Hong Zhang, S. K. Hekmatyar, and Navin Bansal

The problems of monitoring response to chemotherapy in subcutaneously implanted 9L glioma using apparent diffusion coefficient of water and ²³Na magnetic resonance imaging
AACR Meeting Abstracts 2006 2006: B76. [Abstract]  

H. Charles Manning, A. Coe Foutch, Natasha G. Deane, Nipun Merchant, Shelby K. Wyatt, Mingfeng Bai, Darryl J. Bornhop, and Robert J. Coffey, Jr.

A high-throughput molecular imaging screen to monitor therapeutic response in vivo
AACR Meeting Abstracts 2006 2006: B77. [Abstract]  

Targeted Therapies and Clinical Translational Research: Optimization of Clinically Effective Dose and Schedule:

Ignazio Ugo Carreca, Fernanda Bellomo, Giuseppe Bronte, Dario Piazza, Sergio Rizzo, Salvatore Russo, Annapaola Carreca, and Lodovico Balducci

Antiangiogenic scheduling of lower dose chemotherapy in elderly patients with advanced colorectal cancer
AACR Meeting Abstracts 2006 2006: B78. [Abstract]  

Shinji Kawabata, Shin-Ichi Miyatake, Minoru Miyashita, Atsushi Doi, Kyouko Iida, Toshihiko Kuroiwa, Yoshio Imahori, and Koji Ono

• >¹⁸F-labeled BPA positron emmision tomography (PET) based Boron Neutron Capture Therapy on malignant glioma patients in Japan
AACR Meeting Abstracts 2006 2006: B79. [Abstract]  

Targeted Therapies and Clinical Translational Research: Patient Selection/Stratification:

Nicola Personeni, Gert De Hertogh, Maria Debiec-Rychter, Jef De Schutter, Karel Geboes, Eric Van Cutsem, and Sabine Tejpar

Heterogeneity of EGFR and HER2 gene status by fluorescent in situ hybridization in colorectal cancer
AACR Meeting Abstracts 2006 2006: B80. [Abstract]  

Gang Wang, Steve Tahir, Chris Tse, Rick Lesniewski, and Dimitri Semizarov

Genomic analysis of small-cell lung carcinomas: Discovery of a candidate stratification biomarker for a Bcl-2 inhibitor
AACR Meeting Abstracts 2006 2006: B81. [Abstract]  

Mitesh J. Borad, Robert Penny, Michael Bittner, Johanna Gardner, Sonsole Shack, Elizabeth Campbell, Darin Taverna, Richard Love, Jeffrey Trent, and Daniel Von Hoff

Molecular profiling using immunohistochemistry (IHC) and DNA microarray (DMA) as a tool to determine potential therapeutic targets in patients who have progressed on multiple prior therapies
AACR Meeting Abstracts 2006 2006: B82. [Abstract]  

Targeted Therapies and Clinical Translational Research: Other Therapies:

Amanda R. Lowery, Andre M. Gobin, Naomi J. Halas, and Jennifer L. West <